PGxDB

PGxDB (Pharmacogenomics database) is a one-stop shop for pharmacogenomics research offering:

  • Reference data (see Data box)
  • Tools to to compare and customize analysis on high-level indication areas, find and interlink diverse variant effect predictions, associate these to annotated drug response variability associations and interrogate disease or medication associations
  • Tools explore relationship between ATC-level indexed medications, their molecular target profiles in terms of metabolizing enzymes, transporters, and drug targets

Data in PGxDB can be accessed by

  • Any drug
  • Target, enzyme, or transporter
  • Disease
  • Variant
  • Adverse reaction

Drug Anatomical Groups

Drug Clinical Statuses

Protein Super Families

Drug-protein Interaction Modes

Why pharmacogenomics?

Trends in GPCR drug discovery: new agents, targets and indications.
Hauser, A. S., Attwood, M. M., Rask-Andersen, M., Schiöth, H. B., & Gloriam, D. E. (2017).
Nature reviews Drug discovery, 2017, 16(12), 829-842.

Pharmacogenomics of GPCR drug targets.
Hauser, A. S., Chavali, S., Masuho, I., Jahn, L. J., Martemyanov, K. A., Gloriam, D. E., & Babu, M. M. (2018).
Cell 2018, 172(1), 41-54.

Related resources

Drugbank, Genebass, PharmgKB, Ensembl, ChEMBL, UniProt, GRCh38, ClinicalTrials.Gov, SIDER, DisGeNet, and RepurposeDrugs, cover related aspects of how genetic variants affect drug metabolism and drug response.

Release & Accessibility


First release: to be in Aug-2024
Accessibility: This website is freely accessible to all users

Introduction video

Data

  1. 6,259
    Drugs (3,676 with ATC codes)
  2. 1,574
    Indications (diseases) associated with 1,716 drugs in 18,028 associations
  3. 2,937
    Interacting proteins spanning 22,909 drug-protein interactions
  4. 1,212,621
    Unique genetics variants (5,090 influencing drug responses)
  5. 4,897,436
    Variant effects from > 40 algorithms
  6. 2,022,419
    Gene-based association statistics burden test scores
  7. 2,651,948
    Variant-based association statistics burden test scores